RT Journal Article
SR Electronic
T1 Effect of very early intervention with metoprolol on myocardial infarct size.
JF British Heart Journal
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 229
OP 233
DO 10.1136/hrt.49.3.229
VO 49
IS 3
A1 D M Boyle
A1 J M Barber
A1 E L McIlmoyle
A1 K S Salathia
A1 A E Evans
A1 G Cran
A1 J H Elwood
A1 R G Shanks
YR 1983
UL http://heart.bmj.com/content/49/3/229.abstract
AB All patients with a presumptive diagnosis of myocardial infarction, who were seen within six hours of the onset of symptoms and had no reason for exclusion, were considered for entry into a trial to compare the effects of metoprolol and placebo on creatine kinase MB isoenzyme release. The trial was randomised and double blind. The median time from onset of symptoms to receiving trial drug was just under two hours. Two hundred and four patients (of whom 120 had myocardial infarction) received metoprolol and 187 (of whom 105 had myocardial infarction) received placebo. Infarct size was estimated semiquantitatively using cumulative release of the cardiospecific isoenzyme, creatine kinase MB. Mean creatine kinase MB isoenzyme was less in patients who received metoprolol, but the reduction did not achieve statistical significance. Clinical problems related to early intravenous metoprolol were uncommon.