RT Journal Article
SR Electronic
T1 Enzyme tests in the evaluation of thrombolysis in acute myocardial infarction.
JF British Heart Journal
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 175
OP 183
DO 10.1136/hrt.59.2.175
VO 59
IS 2
A1 C de Zwaan
A1 G M Willems
A1 F Vermeer
A1 J Res
A1 F W Verheugt
A1 A van der Laarse
A1 M L Simoons
A1 J Lubsen
A1 W T Hermens
YR 1988
UL http://heart.bmj.com/content/59/2/175.abstract
AB The activity of alpha-hydroxybutyrate dehydrogenase, creatine kinase, creatine kinase MB and aspartate aminotransferase was measured on serial plasma samples from patients with acute myocardial infarction. The study was part of a multicentre randomised trial of the effect of thrombolytic treatment in the acute phase of acute myocardial infarction. The applicability and comparability of enzyme tests for the estimation of myocardial injury were studied in 76 control patients and 74 patients treated with streptokinase. Treatment with streptokinase caused a considerable acceleration of enzyme release after acute myocardial infarction, both in patients with persistent coronary occlusion and in those with successful reperfusion. But this changed pattern of enzyme release did not affect the rate of enzyme elimination from plasma or the released proportions of different enzymes. Thus the assessment of infarct size by measurement of these enzyme activities can also be applied to patients treated with streptokinase. Moreover, the enzymes measured in the present study are all equally valid markers of myocardial injury.