TY - JOUR T1 - Cardiac abnormalities in the fragile X syndrome. JF - British Heart Journal JO - Heart SP - 289 LP - 291 DO - 10.1136/hrt.61.3.289 VL - 61 IS - 3 AU - N Sreeram AU - C Wren AU - M Bhate AU - P Robertson AU - S Hunter Y1 - 1989/03/01 UR - http://heart.bmj.com/content/61/3/289.abstract N2 - Twenty three patients with fragile X syndrome underwent cardiovascular assessment. Echocardiography showed dilatation of the aortic root in 12 (52%) and mitral valve prolapse in five (22%), four of whom had an apical mid-systolic click on auscultation. Patients with fragile X syndrome have cardiac defects similar to those seen in other disorders of connective tissue such as Marfan's syndrome and Ehlers-Danlos syndrome. These, and other somatic features, suggest an underlying connective tissue dysplasia. ER -