PT - JOURNAL ARTICLE AU - C E Denbow AU - E E Chung AU - G R Serjeant TI - Pulmonary artery pressure and the acute chest syndrome in homozygous sickle cell disease. AID - 10.1136/hrt.69.6.536 DP - 1993 Jun 01 TA - British Heart Journal PG - 536--538 VI - 69 IP - 6 4099 - http://heart.bmj.com/content/69/6/536.short 4100 - http://heart.bmj.com/content/69/6/536.full SO - Heart1993 Jun 01; 69 AB - OBJECTIVE--To investigate whether attacks of acute chest syndrome affected pulmonary artery pressure in patients homozygous for sickle cell disease. MAIN OUTCOME MEASURES--Pulmonary artery pressure, assessed by non-invasive echocardiographic techniques. PATIENTS--20 patients with homozygous sickle cell disease with a history of at least six episodes of acute chest syndrome and in 20 age, sex, and height matched controls with homozygous sickle cell disease without a history of acute chest syndrome. RESULTS--There was no difference in any of the echocardiographic or Doppler indices between these two groups. CONCLUSIONS--Repeated attacks of acute chest syndrome by the mean age of 12 (range eight to 16) years have not had a discernible effect upon pulmonary artery pressure.