RT Journal Article
SR Electronic
T1 Pulmonary artery pressure and the acute chest syndrome in homozygous sickle cell disease.
JF British Heart Journal
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 536
OP 538
DO 10.1136/hrt.69.6.536
VO 69
IS 6
A1 C E Denbow
A1 E E Chung
A1 G R Serjeant
YR 1993
UL http://heart.bmj.com/content/69/6/536.abstract
AB OBJECTIVE--To investigate whether attacks of acute chest syndrome affected pulmonary artery pressure in patients homozygous for sickle cell disease. MAIN OUTCOME MEASURES--Pulmonary artery pressure, assessed by non-invasive echocardiographic techniques. PATIENTS--20 patients with homozygous sickle cell disease with a history of at least six episodes of acute chest syndrome and in 20 age, sex, and height matched controls with homozygous sickle cell disease without a history of acute chest syndrome. RESULTS--There was no difference in any of the echocardiographic or Doppler indices between these two groups. CONCLUSIONS--Repeated attacks of acute chest syndrome by the mean age of 12 (range eight to 16) years have not had a discernible effect upon pulmonary artery pressure.