PT  - JOURNAL ARTICLE
AU  - Di Tano, G.
AU  - Mazzù, A.
TI  - Early reactivation of ischaemia after abrupt discontinuation of heparin in acute myocardial infarction.
AID  - 10.1136/hrt.74.2.131
DP  - 1995 Aug 01
TA  - British Heart Journal
PG  - 131--133
VI  - 74
IP  - 2
4099  - http://heart.bmj.com/content/74/2/131.short
4100  - http://heart.bmj.com/content/74/2/131.full
SO  - Heart1995 Aug 01; 74
AB  - Intravenous heparin after thrombolytic therapy for acute myocardial infarction is an effective, widely used treatment. Six cases of acute myocardial infarction are reported with early disease reactivation following the abrupt discontinuation of heparin infusion three days after alteplase thrombolysis and concomitant aspirin therapy. Immediate reinfusion of heparin resulted in regression of symptomatic ischaemia in all six patients. The activated partial thromboplastin time values, determined four hours before the discontinuation of heparin therapy, were within the therapeutic range in five of the six patients, and no difference was found in the values obtained one hour after the reinfusion of heparin (P = 0.065).