RT Journal Article
SR Electronic
T1 Early reactivation of ischaemia after abrupt discontinuation of heparin in acute myocardial infarction.
JF British Heart Journal
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 131
OP 133
DO 10.1136/hrt.74.2.131
VO 74
IS 2
A1 G. Di Tano
A1 A. Mazzù
YR 1995
UL http://heart.bmj.com/content/74/2/131.abstract
AB Intravenous heparin after thrombolytic therapy for acute myocardial infarction is an effective, widely used treatment. Six cases of acute myocardial infarction are reported with early disease reactivation following the abrupt discontinuation of heparin infusion three days after alteplase thrombolysis and concomitant aspirin therapy. Immediate reinfusion of heparin resulted in regression of symptomatic ischaemia in all six patients. The activated partial thromboplastin time values, determined four hours before the discontinuation of heparin therapy, were within the therapeutic range in five of the six patients, and no difference was found in the values obtained one hour after the reinfusion of heparin (P = 0.065).