@article {Tousoulis229, author = {D. Tousoulis and F. Andreotti and D. Hackett and A. W. Haider and A. Maseri and G. Davies}, title = {Early remodelling of coronary stenoses after thrombolytic treatment in patients with acute myocardial infarction.}, volume = {74}, number = {3}, pages = {229--234}, year = {1995}, doi = {10.1136/hrt.74.3.229}, publisher = {BMJ Publishing Group Ltd}, abstract = {OBJECTIVE--To assess the frequency of early remodelling of coronary stenosis morphology after thrombolytic treatment in patients with acute myocardial infarction. DESIGN--Coronary angiograms were analysed by a computerised edge detection analysis system. Coronary stenosis severity was measured and morphology classified as smooth or complex. PATIENTS--Coronary arteriograms were obtained approximately 90 min and 24 h after thrombolytic treatment from 40 patients with acute myocardial infarction. MAIN RESULTS--Stenosis morphology was complex in 22 patients (65\%) and smooth in 11 (32\%) 90 min after thrombolysis. The morphology of 11 (50\%) complex coronary stenoses and three (27\%) smooth stenoses had changed at 24 h (P \< 0.05). The transition from complex to smooth was associated with a reduction in stenosis severity from 65 (4)\% to 51 (5)\% (P \< 0.05). The stenosis severity was 63 (4)\% and 60 (5)\% in those with persistently complex morphology, and 56 (7)\% and 50 (5)\% in those with persistently smooth morphology at 90 min and 24 h respectively (NS). CONCLUSIONS--Transition of morphology from complex to smooth within 24 h is common. This transition is associated with a reduction in stenosis severity of a degree greater than that found in persistently smooth stenoses over the same interval. 50\% of stenoses are smooth at 24 h.}, issn = {0007-0769}, URL = {https://heart.bmj.com/content/74/3/229}, eprint = {https://heart.bmj.com/content/74/3/229.full.pdf}, journal = {Heart} }