TY - JOUR T1 - Hyperhomocysteinaemia, Helicobacter pylori, and coronary heart disease. JF - Heart JO - Heart SP - 305 LP - 307 DO - 10.1136/hrt.76.4.305 VL - 76 IS - 4 AU - J. J. Sung AU - J. E. Sanderson Y1 - 1996/10/01 UR - http://heart.bmj.com/content/76/4/305.abstract N2 - Hyperhomocysteinaemia and Helicobacter pylori infection have recently been implicated in the pathogenesis of coronary artery disease. These two risk factors, though they seem unrelated, could be linked by a deficiency of vitamins and folate caused by chronic gastritis in H pylori infection. This nutritional defect could lead to failure of methylation by 5-methyl-tetrahydrofolic acid and thus exacerbate the accumulation of homocysteine in susceptible patients. Homocysteine is toxic to endothelial cells and results in coronary artery disease. ER -