RT Journal Article
SR Electronic
T1 Plasma concentrations of adrenomedullin correlate with the extent of pulmonary hypertension in patients with mitral stenosis
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 390
OP 395
DO 10.1136/hrt.78.4.390
VO 78
IS 4
A1 Toshio Nishikimi
A1 Seiki Nagata
A1 Tatsuya Sasaki
A1 Shigehiro Tomimoto
A1 Hiroaki Matsuoka
A1 Shuichi Takishita
A1 Kazuo Kitamura
A1 Atsuro Miyata
A1 Hisayuki Matsuo
A1 Kenji Kangawa
YR 1997
UL http://heart.bmj.com/content/78/4/390.abstract
AB Objective To examine the pathophysiological significance of adrenomedullin in the pulmonary circulation by investigating the relation between plasma concentrations of adrenomedullin and central haemodynamics in patients with mitral stenosis. Methods Plasma concentrations of adrenomedullin in blood samples obtained from the femoral vein, pulmonary artery, left atrium, and aorta were measured by a newly developed specific radioimmunoassay in 23 consecutive patients with mitral stenosis (16 females and seven males, aged 53 (10) years (mean (SD)) who were undergoing percutaneous mitral commissurotomy. Results Patients with mitral stenosis had higher concentrations of adrenomedullin than age matched normal controls (3.9 (0.3) v 2.5 (0.3) pmol/l, p < 0.001). There was a reduction in adrenomedullin concentrations between the pulmonary artery and the left atrium (3.8 (0.2) v3.2 (0.4) pmol/l, p < 0.001). The venous concentrations of adrenomedullin correlated with mean pulmonary artery pressure (r = 0.65, p < 0.001), total pulmonary vascular resistance (r = 0.83, p < 0.0001), and pulmonary vascular resistance (r = 0.65, p < 0.001). Plasma concentrations of adrenomedullin did not change immediately after percutaneous mitral commissurotomy; however, they decreased significantly one week later. Conclusions Plasma concentrations of adrenomedullin are increased in patients with mitral stenosis. This may help to attenuate the increased pulmonary arterial resistance in secondary pulmonary hypertension due to mitral stenosis.