RT Journal Article
SR Electronic
T1 Increased plasma adrenomedullin levels in patients with acute myocardial infarction in proportion to the clinical severity
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 39
OP 44
DO 10.1136/hrt.79.1.39
VO 79
IS 1
A1 Yuji Miyao
A1 Toshio Nishikimi
A1 Yoichi Goto
A1 Shunichi Miyazaki
A1 Satoshi Daikoku
A1 Isao Morii
A1 Takahiro Matsumoto
A1 Shuichi Takishita
A1 Atsuro Miyata
A1 Hisayuki Matsuo
A1 Kenji Kangawa
A1 Hiroshi Nonogi
YR 1998
UL http://heart.bmj.com/content/79/1/39.abstract
AB Objectives To investigate the pathophysiological role of adrenomedullin in myocardial infarction.Patients and design Plasma concentrations of adrenomedullin, atrial natriuretic factor, and brain natriuretic peptide were measured by radioimmunoassay in 31 patients with acute myocardial infarction over four weeks, and in 44 normal subjects.Results In patients with acute myocardial infarction, plasma adrenomedullin reached a peak of (mean (SD) 14.0 (9.0) pmol/l at 24 hours after the onset of symptoms and remained increased at all sampling points except the four week point compared with the value in normal subjects (5.0 (2.0) pmol/l). Adrenomedullin concentrations on admission were higher in patients from Killip class II, III, and IV than class I, and correlated positively with peak plasma creatine kinase and left ventricular end diastolic volume index, and negatively with left ventricular ejection fraction. The values from 12 to 48 hours were negatively correlated with systemic vascular resistance index. During the time course studied, adrenomedullin concentrations were positively correlated with atrial natriuretic factor (r = 0.40, p < 0.001) and brain natriuretic peptide (r = 0.53, p < 0.001).Conclusions Plasma adrenomedullin concentrations increased in the acute phase of myocardial infarction in proportion with clinical severity, suggesting that adrenomedullin may play an important role in the pathophysiology of myocardial infarction.