TY - JOUR T1 - Brugada syndrome associated with an autonomic disorder JF - Heart JO - Heart SP - 194 LP - 196 DO - 10.1136/hrt.80.2.194 VL - 80 IS - 2 AU - M Nomura AU - T Nada AU - J Endo AU - Y Kondo AU - M Yukinaka AU - K Saito AU - S Ito AU - H Mori AU - Y Nakaya AU - H Shinomiya Y1 - 1998/08/01 UR - http://heart.bmj.com/content/80/2/194.abstract N2 - A 44 year old man with Brugada syndrome and ventricular fibrillation had an autonomic disorder, shown by spectral analysis of heart rate variability and 123I-MIBG myocardial scintigraphy. Periodic variation of the ST segments was detected by Holter ECG. Increased high frequency power (0.15–0.40 Hz), an index of parasympathetic nerve activity, was observed just before ST segment elevation. In addition, local dysfunction of sympathetic nerves in the left ventricle was detected by 123I-MIBG myocardial scintigraphy. Unbalanced autonomic nerve function plays an important role in inducing Brugada-type ECG signs. ER -