TY - JOUR T1 - Concentrations of angiotensin II, endothelin-1, and BNP in the coronary sinus and ascending aorta of patients with heart disease JF - Heart JO - Heart SP - 102 LP - 103 DO - 10.1136/hrt.81.1.102 VL - 81 IS - 1 AU - YUTAKA KAGAYA AU - HIROKI OTANI AU - TOSHINORI TANIKAWA AU - SHIGETO NAMIUCHI AU - SHOGEN ISOYAMA AU - KUNIO SHIRATO Y1 - 1999/01/01 UR - http://heart.bmj.com/content/81/1/102.abstract N2 - Sir,—It has been well documented that neurohormonal mediators, such as the renin–angiotensin system,1 endothelin,2 and brain natriuretic peptide (BNP),3 are severely activated in patients with congestive heart failure, and that the circulating concentrations of these mediators are good predictors of the severity of congestive heart failure and the prognosis. It has also been demonstrated that both angiotensin II and endothelin-1, like BNP, are locally expressed in cardiac tissue.4-6 It is not clear, however, whether the increase in plasma concentrations of angiotensin II and endothelin-1 is caused by increased expression and spillover from cardiac tissue in patients with … ER -