TY - JOUR T1 - Aspirin JF - Heart JO - Heart SP - 458 LP - 458 DO - 10.1136/hrt.81.5.458 VL - 81 IS - 5 AU - M K DAVIES AU - A HOLLMAN Y1 - 1999/05/01 UR - http://heart.bmj.com/content/81/5/458.abstract N2 - In the 17th and 18th centuries cinchona bark from South America was the preferred treatment for pain and fevers but in 1763 the Reverend Edward Stone of Chipping Norton found that bark of the willow tree,Salix alba, was an effective substitute. By 1829 the active compound had been isolated and … ER -