PT  - JOURNAL ARTICLE
AU  - I Bux-Gewehr
AU  - A Nacke
AU  - G E Feurle
TI  - Recurring myocardial infarction in a 35 year old woman
AID  - 10.1136/hrt.81.3.316
DP  - 1999 Mar 01
TA  - Heart
PG  - 316--317
VI  - 81
IP  - 3
4099  - http://heart.bmj.com/content/81/3/316.short
4100  - http://heart.bmj.com/content/81/3/316.full
SO  - Heart1999 Mar 01; 81
AB  - A 35 year old woman presented with acute myocardial infarction without any of the usual risk factors: she had never smoked; she had normal blood pressure; she did not have diabetes; plasma concentrations of total cholesterol and high and low density lipoprotein cholesterol, fibrinogen, homocysteine, and Lp(a) lipoprotein were normal. She was not taking oral contraceptives or any other medication. Coronary angiography showed occlusion of the left anterior descending coronary artery but no evidence of arteriosclerosis. Medical history disclosed a previous leg vein thrombosis with pulmonary embolism. Coagulation analysis revealed protein C deficiency. The recognition of protein C deficiency as a risk factor for myocardial infarction is important as anticoagulation prevents further thrombotic events, whereas inhibitors of platelet aggregation are ineffective.