RT Journal Article
SR Electronic
T1 Recurring myocardial infarction in a 35 year old woman
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 316
OP 317
DO 10.1136/hrt.81.3.316
VO 81
IS 3
A1 I Bux-Gewehr
A1 A Nacke
A1 G E Feurle
YR 1999
UL http://heart.bmj.com/content/81/3/316.abstract
AB A 35 year old woman presented with acute myocardial infarction without any of the usual risk factors: she had never smoked; she had normal blood pressure; she did not have diabetes; plasma concentrations of total cholesterol and high and low density lipoprotein cholesterol, fibrinogen, homocysteine, and Lp(a) lipoprotein were normal. She was not taking oral contraceptives or any other medication. Coronary angiography showed occlusion of the left anterior descending coronary artery but no evidence of arteriosclerosis. Medical history disclosed a previous leg vein thrombosis with pulmonary embolism. Coagulation analysis revealed protein C deficiency. The recognition of protein C deficiency as a risk factor for myocardial infarction is important as anticoagulation prevents further thrombotic events, whereas inhibitors of platelet aggregation are ineffective.