TY - JOUR T1 - Haemodynamic and hormonal effects of adrenomedullin in patients with pulmonary hypertension JF - Heart JO - Heart SP - 653 LP - 658 DO - 10.1136/heart.84.6.653 VL - 84 IS - 6 AU - N Nagaya AU - T Nishikimi AU - M Uematsu AU - T Satoh AU - H Oya AU - S Kyotani AU - F Sakamaki AU - K Ueno AU - N Nakanishi AU - K Miyatake AU - K Kangawa Y1 - 2000/12/01 UR - http://heart.bmj.com/content/84/6/653.abstract N2 - OBJECTIVE To investigate whether infusion of adrenomedullin, a potent vasorelaxant peptide, has beneficial haemodynamic and hormonal effects in patients with pulmonary hypertension.PATIENTS AND DESIGN The haemodynamic and hormonal responses to intravenous infusion of adrenomedullin (0.05 μg/kg/min) or placebo were examined in 13 patients with precapillary pulmonary hypertension.RESULTS Infusion of adrenomedullin produced a 44% increase in cardiac index (mean (SD) 1.8 (0.2) to 2.6 (0.3) l/min/m2, p < 0.05) and a 32% decrease in pulmonary vascular resistance (19.7 (1.4) to 13.4 (1.3) units, p < 0.05), with a 4% reduction in mean pulmonary arterial pressure (62 (4) to 59 (4) mm Hg, NS). Adrenomedullin also decreased mean systemic arterial pressure (81 (3) to 72 (4) mm Hg, p < 0.05) and increased heart rate (73 (4) to 79 (4) beats/min, p < 0.05). Adrenomedullin decreased plasma aldosterone (9.8 (2.5) to 7.1 (1.5) ng/dl, p < 0.05) without significant changes in plasma renin activity. Plasma atrial and brain natriuretic peptides tended to decrease with adrenomedullin, although these changes did not reach significance. The haemodynamic and hormonal variables remained unchanged during placebo infusion.CONCLUSIONS Intravenous adrenomedullin has beneficial haemodynamic and hormonal effects in patients with precapillary pulmonary hypertension. ER -