TY - JOUR T1 - Interleukin 18 in acute myocardial infarction JF - Heart JO - Heart SP - 668 LP - 669 DO - 10.1136/heart.84.6.668 VL - 84 IS - 6 AU - YUKIHIRO SETA AU - TSUGIYASU KANDA AU - TORU TANAKA AU - MASASHI ARAI AU - KENICHI SEKIGUCHI AU - TOMOYUKI YOKOYAMA AU - MASASHI KURIMOTO AU - JUN'ICHI TAMURA AU - MASAHIKO KURABAYASHI Y1 - 2000/12/01 UR - http://heart.bmj.com/content/84/6/668.1.abstract N2 - Interleukin 18 (IL-18), which is a recently cloned cytokine synthesised by Kupffer cells, has been shown to activate macrophages.1 Macrophages and T cells have been reported to be activated in patients with acute myocardial infarction (MI).2 IL-18 is postulated to play a role in the development of myocardial dysfunction through activation of immune cells. However, the circulating concentration of IL-18 has not been reported in patients with acute MI.To elucidate the changes in the release of IL-18 in patients with coronary artery disease, we examined the correlation between IL-18 concentrations and the serum activities of myocardial enzymes, estimating myocardial necrosis or atrial natriuretic peptide (ANP). Our goal was to determine whether measurement of IL-18 could be used as a new indicator of myocardial damage in patients with acute MI.We evaluated 24 patients with acute MI (19 men and five women aged 39–79 years). … ER -