RT Journal Article
SR Electronic
T1 The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 635
OP 638
DO 10.1136/heart.85.6.635
VO 85
IS 6
A1 J R Ortlepp
A1 R Hoffmann
A1 F Ohme
A1 J Lauscher
A1 F Bleckmann
A1 P Hanrath
YR 2001
UL http://heart.bmj.com/content/85/6/635.abstract
AB OBJECTIVE To test the hypothesis that vitamin D receptor polymorphism is associated with calcific aortic valve stenosis.DESIGN The distribution of one polymorphism of the vitamin D receptor (BsmI B/b) was examined in 100 consecutive patients with calcific valvar aortic stenosis and compared with a control group of 100 patients (paired match for age, sex, and the presence of coronary artery disease from a total of 630 patients without calcified aortic valves). Polymerase chain reaction and restriction fragment length polymorphism were used to determine genotypes.RESULTS There was a significant difference in vitamin D receptor allele and genotype frequencies between the two groups. The allele B had a higher prevalence in patients with calcific aortic stenosis (B = 0.56, b = 0.44) than in the control cohort (B = 0.40, b = 0.60) (p = 0.001).CONCLUSIONS There is a significant association of vitamin D receptor polymorphism with calcific aortic valve stenosis. The B allele of the vitamin D receptor is more common in patients with calcific aortic valve stenosis. It now needs to be evaluated whether other genes that control calcium homeostasis are involved in the pathogenesis of this disorder.