PT  - JOURNAL ARTICLE
AU  - H C Lowe
AU  - M Mino
AU  - E J Mark
AU  - B D Mac Neill
AU  - I F Palacios
AU  - S L Houser
TI  - Histopathology of coronary in-stent restenosis following γ brachytherapy
AID  - 10.1136/heart.89.1.11
DP  - 2003 Jan 01
TA  - Heart
PG  - 11--13
VI  - 89
IP  - 1
4099  - http://heart.bmj.com/content/89/1/11.short
4100  - http://heart.bmj.com/content/89/1/11.full
SO  - Heart2003 Jan 01; 89
AB  - The histopathology of in-stent restenosis (ISR) following γ brachytherapy is described. Such histology has not been reported previously. An 82 year old man presented with recurrent ISR three months after γ brachytherapy to an area of ISR within a native circumflex vessel. The recurrent ISR was treated with directional coronary atherectomy; the histopathology of this directional coronary atherectomy specimen is discussed. These histopathological examinations showed abundant extracellular matrix material. Surprisingly, there was a relatively small cellular (myofibroblastic) component, with an absence of endothelial cells and little evidence of active proliferation. ISR after γ brachytherapy may be a pathologically distinct entity.