RT Journal Article
SR Electronic
T1 Histopathology of coronary in-stent restenosis following γ brachytherapy
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 11
OP 13
DO 10.1136/heart.89.1.11
VO 89
IS 1
A1 H C Lowe
A1 M Mino
A1 E J Mark
A1 B D Mac Neill
A1 I F Palacios
A1 S L Houser
YR 2003
UL http://heart.bmj.com/content/89/1/11.abstract
AB The histopathology of in-stent restenosis (ISR) following γ brachytherapy is described. Such histology has not been reported previously. An 82 year old man presented with recurrent ISR three months after γ brachytherapy to an area of ISR within a native circumflex vessel. The recurrent ISR was treated with directional coronary atherectomy; the histopathology of this directional coronary atherectomy specimen is discussed. These histopathological examinations showed abundant extracellular matrix material. Surprisingly, there was a relatively small cellular (myofibroblastic) component, with an absence of endothelial cells and little evidence of active proliferation. ISR after γ brachytherapy may be a pathologically distinct entity.