RT Journal Article
SR Electronic
T1 Long term follow up of children with myocarditis treated by immunosuppression and of children with dilated cardiomyopathy
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1167
OP 1171
DO 10.1136/hrt.2003.026641
VO 90
IS 10
A1 Gagliardi, M Giulia
A1 Bevilacqua, M
A1 Bassano, C
A1 Leonardi, B
A1 Boldrini, R
A1 Camassei, F Diomedi
A1 Fierabracci, A
A1 Ugazio, A G
A1 Bottazzo, G F
YR 2004
UL http://heart.bmj.com/content/90/10/1167.abstract
AB Objective: To describe the treatment and long term outcome after immunosuppressive treatment of children with myocarditis. Methods and results: 114 patients with newly diagnosed dilated cardiomyopathy were divided into three groups, according to the histological pattern: group A, acute myocarditis; group B, borderline myocarditis; and group C, non-inflammatory cardiomyopathy. Groups A and B were treated with cyclosporine and prednisone in addition to conventional treatment. Survivors of the whole cohort were analysed for 13 year transplant-free survival and assessed for left ventricular function. Event-free survival at 13 years was 97 (3)% for group A, 70 (8)% for group B, and 32 (7)% for group C (p < 0.0001). It was 96 (4)% at one year and 83 (5)% at 13 years for the cumulated myocarditis group (A and B). Cardiac function recovered completely in 79% of survivors in group A, 64% in group B, and 36% in group C. The rate of complete recovery in the cumulated group (A and B) was 70%. Conclusions: The high long term survival rate of this cohort of children with myocarditis is probably due to the effect of short term immunosuppression. This result differs from previously published series of conventionally treated children, whose survival probability at one year was about 60%.