PT  - JOURNAL ARTICLE
AU  - K Miwa
AU  - T Higashikata
AU  - H Mabuchi
TI  - Intravascular ultrasound findings of coronary wall morphology in a patient with pseudoxanthoma elasticum
AID  - 10.1136/hrt.2004.040592
DP  - 2004 Oct 01
TA  - Heart
PG  - e61--e61
VI  - 90
IP  - 10
4099  - http://heart.bmj.com/content/90/10/e61.short
4100  - http://heart.bmj.com/content/90/10/e61.full
SO  - Heart2004 Oct 01; 90
AB  - Pseudoxanthoma elasticum (PXE) is an inherited disorder characterised by progressive calcification of the elastic fibres in the skin, eye, and cardiovascular system. Recently, mutations in the ATP binding cassette transporter gene (ABCC6) were identified as cause of this disease. Although patients with PXE often have coronary artery disease, little is known about the process and the mechanism of coronary artery disease in PXE. In this report, intravascular ultrasound (IVUS) imaging was performed in a female patient with PXE seven years after the onset of skin lesion to assess the coronary wall morphology in detail. IVUS showed a unique five layer appearance without acoustic shadowing along the vessel wall observed in the angiographically normal portion. These findings may reflect the earlier stage of coronary artery disease caused by PXE before calcification of the internal elastic laminae.