RT Journal Article SR Electronic T1 Intravascular ultrasound findings of coronary wall morphology in a patient with pseudoxanthoma elasticum JF Heart JO Heart FD BMJ Publishing Group Ltd and British Cardiovascular Society SP e61 OP e61 DO 10.1136/hrt.2004.040592 VO 90 IS 10 A1 K Miwa A1 T Higashikata A1 H Mabuchi YR 2004 UL http://heart.bmj.com/content/90/10/e61.abstract AB Pseudoxanthoma elasticum (PXE) is an inherited disorder characterised by progressive calcification of the elastic fibres in the skin, eye, and cardiovascular system. Recently, mutations in the ATP binding cassette transporter gene (ABCC6) were identified as cause of this disease. Although patients with PXE often have coronary artery disease, little is known about the process and the mechanism of coronary artery disease in PXE. In this report, intravascular ultrasound (IVUS) imaging was performed in a female patient with PXE seven years after the onset of skin lesion to assess the coronary wall morphology in detail. IVUS showed a unique five layer appearance without acoustic shadowing along the vessel wall observed in the angiographically normal portion. These findings may reflect the earlier stage of coronary artery disease caused by PXE before calcification of the internal elastic laminae.