PT  - JOURNAL ARTICLE
AU  - H J Ankersmit
AU  - T Weber
AU  - J Auer
AU  - G Roth
AU  - M Brunner
AU  - E Kvas
AU  - B Moser
AU  - S Spreitzer
AU  - E Lassnig
AU  - E Maurer
AU  - P Hartl
AU  - E Wolner
AU  - G Boltz-Nitulescu
AU  - B Eber
TI  - Increased serum concentrations of soluble CD95/Fas and caspase 1/ICE in patients with acute angina
AID  - 10.1136/hrt.2003.012062
DP  - 2004 Feb 01
TA  - Heart
PG  - 151--154
VI  - 90
IP  - 2
4099  - http://heart.bmj.com/content/90/2/151.short
4100  - http://heart.bmj.com/content/90/2/151.full
SO  - Heart2004 Feb 01; 90
AB  - Objectives: To investigate the expression of death inducing receptors in the sera of patients with stable and unstable angina. Design: 80 consecutive patients with stable (n  =  40) or unstable (n  =  40) angina pectoris were studied. Serum concentrations of soluble CD95 (sCD95), soluble CD95 ligand (sCD95L; CD178), tumour necrosis factor (TNF) α, soluble TNFα receptor type 1 (sTNFR1), and interleukin 1β converting enzyme (ICE; caspase 1) were measured by enzyme linked immunosorbent assay (ELISA). Results: Significant increases in the concentrations of sCD95 and ICE (p < 0.001 and p < 0.023, respectively) were found in the serum from patients with unstable angina relative to those with stable angina. There were no significant differences in the concentrations of sCD95L, TNF α, and sTNFR1 between the groups. Conclusions: These data provide the first evidence that sCD95 and ICE are important serological markers that may help to discriminate between stable and unstable angina. This observation may warrant further clinical study to elucidate the clinical impact of sCD95 and ICE in acute coronary syndromes.