PT  - JOURNAL ARTICLE
AU  - F Andersohn
AU  - F G Hagmann
AU  - E Garbe
TI  - Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome associated with clopidogrel: report of two new cases
AID  - 10.1136/hrt.2004.039214
DP  - 2004 Sep 01
TA  - Heart
PG  - e57--e57
VI  - 90
IP  - 9
4099  - http://heart.bmj.com/content/90/9/e57.short
4100  - http://heart.bmj.com/content/90/9/e57.full
SO  - Heart2004 Sep 01; 90
AB  - Clopidogrel has been reported to be safe and effective in reducing vascular events. Nevertheless, there is growing evidence that clopidogrel may cause thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS). This association has been debated, since in several cases alternative causes could not be excluded. Two new cases of TTP/HUS associated with clopidogrel are reported here. After discontinuation of clopidogrel and treatment with plasma exchange, both patients had a complete and sustained recovery from TTP/HUS. These cases corroborate previous observations that clopidogrel may indeed be a rare cause of TTP/HUS.