RT Journal Article
SR Electronic
T1 Warfarin: a case history in pharmacogenetics
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 563
OP 564
DO 10.1136/hrt.2004.051771
VO 91
IS 5
A1 A M Hall
A1 M R Wilkins
YR 2005
UL http://heart.bmj.com/content/91/5/563.abstract
AB Both hereditary and environmental factors contribute to inter-individual variability in drug response. The considerable interest in the role of genes has to be balanced with the contribution of external influences. Warfarin provides a useful case study of the need to integrate both genetic and non-genetic information when selecting the right dose for a patient. This article discusses the latest data on genotype and warfarin sensitivity and the efforts to incorporate this information into normograms. Exploring the genetics of warfarin response will lead not only to safer prescribing but elucidate the mechanism of action of warfarin and enable the development of new anticoagulant drugs.