TY - JOUR T1 - B-type natriuretic peptide can detect silent myocardial ischaemia in asymptomatic type 2 diabetes JF - Heart JO - Heart SP - 916 LP - 920 DO - 10.1136/hrt.2005.071423 VL - 92 IS - 7 AU - B S Rana AU - J I Davies AU - M M Band AU - S D Pringle AU - A Morris AU - A D Struthers Y1 - 2006/07/01 UR - http://heart.bmj.com/content/92/7/916.abstract N2 - Objective: To find out whether B-type natriuretic peptide (BNP) detects silent myocardial ischaemia in patients with type 2 diabetes, since many of these patients have silent ischaemia leading to unexpected cardiac deaths. Design: Prospective cross-sectional study with consecutive recruitment of patients. Setting: Outpatient, single centre. Patients: 219 patients with type 2 diabetes. Patients were excluded if they had a history or evidence of cardiac failure. Outcome measures: BNP, echocardiography and exercise tolerance test (ETT). BNP was compared with the ETT result in all patients and specifically in those who had no apparent ischaemic heart disease (IHD). Results: 121 patients had no history of IHD or cardiac failure and of these patients 85 had a clearly abnormal or normal ETT result. BNP was higher in patients with an abnormal than with a normal ETT (mean 58.2 (SD 46.3) v 24.4 (SD 15.7) pg/ml, p < 0.001). In univariate analysis BNP was an independent predictor of an abnormal ETT (p < 0.001). In multivariate analysis BNP remained an independent predictor of the ETT result. BNP concentration over 20 pg/ml predicted an abnormal ETT result with a sensitivity of 87% and specificity of 37%, and BNP over 40 pg/ml had a sensitivity of 63% and a specificity of 81%. Conclusion: BNP is of value in predicting silent ischaemia on exercise testing in asymptomatic patients with type 2 diabetes. ER -