PT  - JOURNAL ARTICLE
AU  - De Castro, Stefano
AU  - Caselli, Stefano
AU  - Maron, Martin
AU  - Pelliccia, Antonio
AU  - Cavarretta, Elena
AU  - Maddukuri, Prasad
AU  - Cartoni, Domenico
AU  - Di Angelantonio, Emanuele
AU  - Kuvin, Jeffrey T
AU  - Patel, Ayan R
AU  - Pandian, Natesa G
TI  - Left ventricular remodelling index (LVRI) in various pathophysiological conditions: a real-time three-dimensional echocardiographic study
AID  - 10.1136/hrt.2006.093997
DP  - 2007 Feb 01
TA  - Heart
PG  - 205--209
VI  - 93
IP  - 2
4099  - http://heart.bmj.com/content/93/2/205.short
4100  - http://heart.bmj.com/content/93/2/205.full
SO  - Heart2007 Feb 01; 93
AB  - Background: Various studies have reported a close correlation between real-time three-dimensional echocardiography (RT3DE) and cine magnetic resonance imaging studies for the assessment of cardiac volumes and mass. Objective: The aim of our study was to evaluate changes in left ventricular volumes and mass in subjects with different pathophysiological conditions. A ratio between left ventricular mass and end-diastolic volume (LVRI), detected by RT3DE, was used to describe various patterns of left ventricular remodelling. Methods: RT3DE was performed to calculate left ventricular end-diastolic (LVEDV) and end-systolic volume (LVESV), ejection fraction (LVEF) and mass in 220 selected subjects. Of these, 152 were healthy volunteers, 19 top-level rowers, 23 patients with dilated cardiomyopathy and 26 patients with hypertrophic cardiomyopathy. Off-line analysis was performed by two independent operators by tracing manual endocardial and epicardial borders of the left ventricle through eight cutting planes. Inter- and intra-observer variability were calculated. Results: Despite the increase in LV volume and mass in the rowers, LVRI remained unchanged compared with control subjects (p = 0.455), while significantly lower values were found patients with dilated cardiomyopathy (p<0.001) and significantly higher values in patients with hypertrophic cardiomyopathy (p<0.001). There was inter- and intra-observer variability. Conclusion: The LVRI may serve as a simple and useful indicator of left ventricular adaptation to physiological and pathological conditions.