PT  - JOURNAL ARTICLE
AU  - Alper O Onbasili
AU  - Yavuz Yeniceriglu
AU  - Pınar Agaoglu
AU  - Aslıhan Karul
AU  - Tarkan Tekten
AU  - Harun Akar
AU  - Guzel Discigil
TI  - Trimetazidine in the prevention of contrast-induced nephropathy after coronary procedures
AID  - 10.1136/hrt.2006.097477
DP  - 2007 Jun 01
TA  - Heart
PG  - 698--702
VI  - 93
IP  - 6
4099  - http://heart.bmj.com/content/93/6/698.short
4100  - http://heart.bmj.com/content/93/6/698.full
SO  - Heart2007 Jun 01; 93
AB  - Objective: To evaluate the efficacy of trimetazidine (TMZ) in the prevention of contrast-induced nephropathy (CIN) in patients with high serum creatinine levels undergoing coronary angiography/angioplasty. Methods: TMZ (20 mg thrice daily) was administered orally for 72 h starting 48 h before the procedure. All patients were given intravenous saline (0.9%) at a rate of 1 ml/kg of body weight per hour for 24 h starting 12 h beforehand. Serum creatinine levels were measured before the procedure, 48 h and 7 days after the procedure. Increase in serum creatinine level exceeding 0.5 mg/day or one quarter of the basal value is considered as CIN. Venous blood samples for serum total antioxidant capacity (TAC) measurement were drawn before and after coronary angiography. Results: Basal serum creatinine levels and TAC were similar in TMZ and control groups. Serum creatinine levels in the control group increased significantly 2 days after the procedure, and returned to the baseline values on the seventh day. However, it did not change significantly on the second day, and even significantly decreased on the seventh day in the TMZ group. CIN developed in 2.5% (1/40) of patients in the TMZ group and in 16.6% (7/42) of patients in the control group (p<0.05). TAC values were not different between treatment groups. Conclusion: TMZ along with isotonic saline infusion is more effective than isotonic saline alone in reducing the risk of CIN in patients with pre-existing renal dysfunction.