RT Journal Article
SR Electronic
T1 Association of coronary plaque composition and arterial remodelling: a virtual histology analysis by intravascular ultrasound
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 928
OP 932
DO 10.1136/hrt.2006.102111
VO 93
IS 8
A1 Jean-François Surmely
A1 Kenya Nasu
A1 Hiroshi Fujita
A1 Mitsuyasu Terashima
A1 Tetsuo Matsubara
A1 Etsuo Tsuchikane
A1 Mariko Ehara
A1 Yoshihisa Kinoshita
A1 Yoshihiro Takeda
A1 Nobuyoshi Tanaka
A1 Osama Katoh
A1 Takahiko Suzuki
YR 2007
UL http://heart.bmj.com/content/93/8/928.abstract
AB Background: Conflicting data have been reported about the correlation between plaque composition assessed by virtual histology (VH) and remodelling index (RI).Aim: To evaluate, in a larger patient population, the relationship between plaque morphology obtained by VH and arterial remodelling.Methods and results: VH intravascular ultrasound was performed on 95 non-bifurcation native significant lesions (>75% stenosis) in 85 patients. Positive remodelling (defined as RI ⩾1.05) was present in 28 lesions, whereas intermediate/negative remodelling (RI <1.05) was present in 67 lesions. Compared with intermediate/negative remodelling, positive remodelling was associated with an increased frequency of patients with acute coronary syndrome (n = 13 (52%) vs n = 15 (25%); p = 0.017), and with a greater plaque burden (mean (SD) 78.3 (6.3)% vs 73.2 (6.8)%, p = 0.001). At the minimal lumen site, necrotic core was significantly smaller in lesions with positive remodelling (median (interquartile range) 5.0% (2.2–11.0%)) than in lesions with intermediate/negative remodelling (median (interquartile range) 9.0% (4.0–16.0%); p = 0.048). No differences were observed in the rate of thin-cap fibroatheroma or in the presence of multiple necrotic core layers, and there were no statistical differences for fibrous, fibro fatty and dense calcium percent plaque area at the minimum lumen diameter (MLD), or for the entire lesion length between both groups.Conclusions: In vivo VH analysis shows that lesions with positive remodelling have statistically less necrotic core percent area at the MLD site compared with intermediate/negative remodelling lesions.