TY - JOUR T1 - Statins in elderly patients with acute coronary syndrome: an analysis of dose and class effects in typical practice JF - Heart JO - Heart SP - 945 LP - 951 DO - 10.1136/hrt.2006.110197 VL - 93 IS - 8 AU - Niteesh K Choudhry AU - Raisa Levin AU - Wolfgang C Winkelmayer Y1 - 2007/08/01 UR - http://heart.bmj.com/content/93/8/945.abstract N2 - Objective: To compare the effectiveness of statins of different treatment intensity used to treat elderly patients with acute coronary syndrome (ACS) in typical care settings.Design: Retrospective cohort study using linked hospital and pharmacy claims data.Setting: Statewide pharmacy benefits programmes in Pennsylvania and New Jersey.Participants: 18 311 Medicare patients discharged alive after ACS who received a prescription for a statin within 90 days of hospital discharge.Main outcome measures: Using multivariable and propensity-matched Cox proportional hazards regression models, patients who were prescribed high-intensity and moderate-intensity statins were compared based on the drug–dose combination that they initially received. Individual drug–dose combinations were also compared. Our primary outcome was the composite of all-cause death or recurrent ACS.Results: Patients who received moderate-intensity statins were as likely to experience a primary outcome as patients treated with high-intensity statins (adjusted HR 1.02, 95% CI 0.96 to 1.08). Propensity matching did not change the results. Individually, all moderate-intensity statins were as effective as high-intensity atorvastatin with the exception of lovastatin (adjusted HR 1.22, 95% CI 1.09 to 1.36). Similarly, all high-intensity statins seem as effective as high-intensity atorvastatin but the CIs surrounding these estimates were wide.Conclusions: This analysis of elderly patients with ACS treated in typical care settings does not demonstrate the superiority of high-intensity over moderate-intensity statin treatment or significant differences among individual statins. ER -