RT Journal Article
SR Electronic
T1 Gene therapy: targeting the myocardium
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 89
OP 99
DO 10.1136/hrt.2007.116483
VO 94
IS 1
A1 Lyon, A R
A1 Sato, M
A1 Hajjar, R J
A1 Samulski, R J
A1 Harding, S E
YR 2008
UL http://heart.bmj.com/content/94/1/89.abstract
AB Effective clinical delivery of gene therapy to the heart requires understanding and design of complex biological systems to deliver therapeutic gene expression. The development of vectors that specifically target the myocardium, in particular bioengineered recombinant viruses, has improved the efficiency of gene delivery to the heart. These tools, coupled with advances in selection and design of the genetic payload, have led to effective cardiac gene therapy in preclinical models. This technology is currently translating to the clinic with a new wave of gene therapy trials for myocardial disease.