RT Journal Article
SR Electronic
T1 Obstructive hypertrophic cardiomyopathy is associated with enhanced thrombin generation and platelet activation
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP e21
OP e21
DO 10.1136/hrt.2007.126896
VO 94
IS 6
A1 P P Dimitrow
A1 A Undas
A1 M Bober
A1 W Tracz
A1 J S Dubiel
YR 2008
UL http://heart.bmj.com/content/94/6/e21.abstract
AB Objectives: To investigate the association of left ventricular outflow tract (LVOT) obstruction with blood coagulation, platelet activity and inflammatory response in patients with hypertrophic cardiomyopathy (HCM) and sinus rhythm.Patients and main outcome measures: In 42 patients with HCM with sinus rhythm, including 16 patients with resting LVOT obstruction (gradient ⩾30 mm Hg) and 29 age- and sex-matched controls, markers of thrombin generation (thrombin–antithrombin complex (TAT), prothrombin fragment 1+2 (F1+2)), platelet activation (soluble CD40 ligand (sCD40L), β-thromboglobulin (β-TG), P-selectin) and inflammation (C-reactive protein (CRP), interleukin (IL)6, tumour necrosis factor-α (TNFα)) were determined.Results: Thrombin, platelet and inflammatory markers were higher in the entire HCM group than in controls (p<0.005 for all compared parameters). Compared with non-obstructive HCM, obstructive HCM was associated with increased thrombin formation (TAT, F1+2), platelet activation (sCD40L, β-TG, P-selectin) and both CRP and IL6 levels. Only the level of TNFα was similar in both forms of HCM. In contrast, a comparison of non-obstructive HCM with controls showed that all these variables (except for P-selectin) were similar; P-selectin was higher in non-obstructive HCM. The LVOT gradient correlated positively with all the raised blood markers (r from 0.39 to 0.73; p<0.05), except for TNFα. In multiple regression analysis models, the LVOT gradient was the only independent predictor of TAT (R2 = 0.61; p<0.001), sCD40L (R2 = 0.59; p<0.001), F1+2 (R2 = 0.55; p = 0.002), P-selectin (R2 = 0.49; p = 0.004) and β-TG (R2 = 0.38; p = 0.005) in patients with HCM.Conclusions: LVOT obstruction is independently associated with enhanced thrombin generation and platelet activity in patients with HCM with sinus rhythm.