TY - JOUR T1 - Emergence of the concept of platelet reactivity monitoring of response to thienopyridines JF - Heart JO - Heart SP - 1214 LP - 1219 DO - 10.1136/hrt.2008.152660 VL - 95 IS - 15 AU - L Bonello AU - A De Labriolle AU - M Scheinowitz AU - G Lemesle AU - P Roy AU - D H Steinberg AU - T L Pinto Slottow AU - R Pakala AU - A D Pichard AU - P Barragan AU - L Camoin-Jau AU - F Dignat-George AU - F Paganelli AU - R Waksman Y1 - 2009/08/01 UR - http://heart.bmj.com/content/95/15/1214.abstract N2 - Clinical trials have demonstrated the beneficial impact of clopidogrel in preventing major adverse cardiovascular events (MACE), particularly in patients undergoing percutaneous coronary intervention (PCI). The concept of biological clopidogrel resistance emerged with the finding of persistent platelet activation despite clopidogrel therapy in some patients. Further, a link between biological clopidogrel resistance and thrombotic recurrence after PCI was observed and a threshold of platelet reactivity (PR) for thrombotic events was suggested. Consistently, in recent trials, enhanced PR inhibition translated into a reduction in the rate of MACE after PCI. This review aims to present the emergence of the concept of PR monitoring in patients undergoing PCI following recent advances in this field. ER -