RT Journal Article
SR Electronic
T1 Immediate clinical and haemodynamic benefits of restoration of pulmonary valvar competence in patients with pulmonary hypertension
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 646
OP 650
DO 10.1136/hrt.2008.153379
VO 95
IS 8
A1 P Lurz
A1 J Nordmeyer
A1 L Coats
A1 A M Taylor
A1 P Bonhoeffer
A1 I Schulze-Neick
YR 2009
UL http://heart.bmj.com/content/95/8/646.abstract
AB Objective: To analyse the potential benefit of restoration of pulmonary valvar competence in patients with severe pulmonary regurgitation (PR) and pulmonary hypertension (PH) associated with congenital heart disease. Design: Retrospective study. Setting: Tertiary paediatric and adult congenital heart cardiac centre. Interventions: Percutaneous pulmonary valve implantation (PPVI). Patients: All patients who underwent PPVI for treatment of PR in the presence of PH (mean PAP >25 mm Hg). Results: Seven patients with severe PH as a result of congenital heart disease and severe PR underwent PPVI. The valve implantation procedure was feasible and uncomplicated in all seven cases, successfully abolishing PR. There was a significant increase in diastolic (15.4 (7.3) to 34.0 (8.5) mm Hg; p = 0.007) and mean (29.7 (8.1) to 41.3 (12.9) mm Hg; p = 0.034) pulmonary artery pressures, and an improvement in NYHA functional class (from median IV to median III; p<0.008). Peripheral oxygen saturations rose from 85.9% (11.0%) to 91.7% (8.3%) (p = 0.036). Right ventricular (RV) volumes decreased (from 157.0 (44.7) to 140.3 (53.3) ml/m2), while effective RV stroke volume increased (from 23.4 (9.3) to 41.0 (11.6) ml/m2). During a median follow-up of 20.3 months (range 1.3–47.5), valvar competence was well maintained despite near systemic pulmonary pressures. None of the valved stents were explanted during follow-up. Conclusion: Trans-catheter treatment of PR in patients with PH is well tolerated and leads to clinical and haemodynamic improvement, most probably caused by a combination of increased pulmonary perfusion pressures and RV efficiency.