PT  - JOURNAL ARTICLE
AU  - F F Faletra
AU  - I D'Angeli
AU  - C Klersy
AU  - M Averaimo
AU  - J Klimusina
AU  - E Pasotti
AU  - G B Pedrazzini
AU  - M Curti
AU  - C Carraro
AU  - R DiLiberto
AU  - T Moccetti
AU  - A Auricchio
TI  - Estimates of lifetime attributable risk of cancer after a single radiation exposure from 64-slice computed tomographic coronary angiography
AID  - 10.1136/hrt.2009.186973
DP  - 2010 Jun 01
TA  - Heart
PG  - 927--932
VI  - 96
IP  - 12
4099  - http://heart.bmj.com/content/96/12/927.short
4100  - http://heart.bmj.com/content/96/12/927.full
SO  - Heart2010 Jun 01; 96
AB  - Aims To estimate the life attributable risk (LAR) of cancer incidence over a wide range of dose radiation exposure and a large spectrum of possible diagnostic computed tomographic coronary angiography (CTCA) scenarios.Methods This study included 561 consecutive patients who underwent a successful prospective ECG-gating CTCA protocol (low-dose group) 64-slice CTCA and 188 patients who underwent retrospective ECG-gating CTCA with ECG-triggered dose modulation CTCA (high-dose group). LAR was computed, given the organ equivalent dose, for all cancers in both sexes. LAR was tabulated for each decile of dose-length product by 10-year age classes, separately for each sex.Results Estimates of LAR of any cancer for an exposure at age ≤40 year were lower in males than in females for any given quantile. At age ≥50years, LAR was similar between sexes only at the lowest exposure doses, whereas at higher dosage, it was, in general, higher for women. At the median age of this case series (62 years) and for a radiation exposure ranging from 1.33 to 3.81 mSv, LAR was 1 in 4329 (or 23.1 per 105 persons exposed) and 1 in 4629 (or 21.6 per 105 persons) in men and women, respectively. For an exposure ranging from 10.34 to 18.97 mSv at the same median age, the LAR of cancer incidence was 1 in 1336 (or 74.8 per 105 persons) in men and doubled (1 in 614 or 162.8 per 105 persons) in women.Conclusions This study provided an estimate of the LAR of cancer in middle-aged patients of both sexes after a single diagnostic CTCA, providing an easy-to-read table.