TY - JOUR T1 - Impact of early statin therapy on development of atrial fibrillation at the acute stage of myocardial infarction: data from the FAST-MI register JF - Heart JO - Heart SP - 1809 LP - 1814 DO - 10.1136/hrt.2010.201574 VL - 96 IS - 22 AU - Nicolas Danchin AU - Laurent Fauchier AU - Eloi Marijon AU - Claude Barnay AU - Alain Furber AU - Philippe Mabo AU - Paul Bernard AU - Jean-Jacques Blanc AU - Xavier Jouven AU - Jean-Yves Le Heuzey AU - Bernard Charbonnier AU - Jean Ferrières AU - Tabassome Simon AU - for the French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) Investigators Y1 - 2010/11/01 UR - http://heart.bmj.com/content/96/22/1809.abstract N2 - Background Atrial fibrillation developing at the acute stage of myocardial infarction is associated with untoward clinical outcomes. The aim of this study was to determine correlations between early statin therapy and atrial fibrillation in acute myocardial infarction.Methods Patients (3396) with sinus rhythm developing acute myocardial infarction were enrolled in the French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI).Results Atrial fibrillation developed in 7.0% of patients without and 3.9% of patients with early (≤48 h of admission) statin therapy (p<0.001). Multivariable analysis, including the propensity score for early statin treatment, showed that statin therapy was associated with reduced risk of atrial fibrillation (OR 0.64; 95% CI 0.45 to 0.92, p=0.017). Compared to patients without early statin therapy, the OR for atrial fibrillation were 0.72 (0.49 to 1.04, p=0.080), 0.52 (0.28 to 0.95, p=0.034) and 0.40 (0.18 to 0.92, p=0.030) in patients on conventional, intermediate and high doses respectively.Conclusions This study is the first to document a correlation between early statin therapy and atrial fibrillation at the early stage of acute myocardial infarction. ER -