TY - JOUR T1 - Coronary collateral growth by external counterpulsation: a randomised controlled trial JF - Heart JO - Heart SP - 202 LP - 207 DO - 10.1136/hrt.2009.184507 VL - 96 IS - 3 AU - Steffen Gloekler AU - Pascal Meier AU - Stefano F de Marchi AU - Tobias Rutz AU - Tobias Traupe AU - Stefano F Rimoldi AU - Kerstin Wustmann AU - Hélène Steck AU - Stéphane Cook AU - Rolf Vogel AU - Mario Togni AU - Christian Seiler Y1 - 2010/02/01 UR - http://heart.bmj.com/content/96/3/202.abstract N2 - Background The efficacy of external counterpulsation (ECP) on coronary collateral growth has not been investigated in a randomised controlled study.Objective To test the hypothesis that ECP augments collateral function during a 1 min coronary balloon occlusion.Patients and methods Twenty patients with chronic stable coronary artery disease were studied. Before and after 30 h of randomly allocated ECP (20 90 min sessions over 4 weeks at 300 mm Hg inflation pressure) or sham ECP (same setting at 80 mm Hg inflation pressure), the invasive collateral flow index (CFI, no unit) was obtained in 34 vessels without coronary intervention. CFI was determined by the ratio of mean distal coronary occlusive pressure to mean aortic pressure with central venous pressure subtracted from both. Additionally, coronary collateral conductance (occlusive myocardial blood flow per aorto-coronary pressure drop) was determined by myocardial contrast echocardiography, and brachial artery flow-mediated dilatation was obtained.Results CFI changed from 0.125 (0.073; interquartile range) at baseline to 0.174 (0.104) at follow-up in the ECP group (p=0.006), and from 0.129 (0.122) to 0.111 (0.125) in the sham ECP group (p=0.14). Baseline to follow-up change of coronary collateral conductance was from 0.365 (0.268) to 0.568 (0.585) ml/min/100 mm Hg in the ECP group (p=0.072), and from 0.229 (0.212) to 0.305 (0.422) ml/min/100 mm Hg in the sham ECP group (p=0.45). There was a correlation between the flow-mediated dilatation change from baseline to follow-up and the corresponding CFI change (r=0.584, p=0.027).Conclusions ECP appears to be effective in promoting coronary collateral growth. The extent of collateral function improvement is related to the amount of improvement in the systemic endothelial function. ER -