RT Journal Article
SR Electronic
T1 Control of free fatty acids during acute myocardial ischaemia
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1883
OP 1884
DO 10.1136/hrt.2010.205534
VO 96
IS 23
A1 Michael F Oliver
YR 2010
UL http://heart.bmj.com/content/96/23/1883.abstract
AB During the onset of an acute coronary syndrome, an immediate increase in plasma free fatty acid (FFA) concentrations presents the ischaemic underperfused myocardium with a metabolic challenge to its survival. For the maintenance of contraction and to counter ventricular arrhythmias, parenteral treatment to reduce FFA availability should be available for paramedics when the patient is first seen. The best treatment options are insulin which partly inhibits FFA release from adipose tissue, immediate reduction of adipose tissue lipolysis, perhaps by new analogues of nicotinic acid, or measures to decrease the FFA/molar binding ratio with albumin. None has yet been tested in appropriate clinical trials.