TY - JOUR T1 - 004 Peroxisome proliferator-activated receptor alpha is essential for cardiac adaptation to chronic hypoxia JF - Heart JO - Heart SP - e1 LP - e2 DO - 10.1136/hrt.2009.191049d VL - 96 IS - 4 AU - M Cole Y1 - 2010/02/01 UR - http://heart.bmj.com/content/96/4/e1.4.abstract N2 - Deletion of the peroxisome proliferator-activated receptor alpha (PPARα) gene in mice results in abnormal cardiac substrate metabolism and PPARα−/− hearts have impaired function at high workload and increased post-ischaemic infarct size. We hypothesised that PPARα−/− mouse hearts would be intolerant to chronic hypoxia, and that PPARα is an essential regulator of … ER -