RT Journal Article
SR Electronic
T1 e0449 Effects of cholesterol-lowering therapy with rosuvastatin calcium tablet on coronary flow reserve in patients with unstable angina pectoris
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP A140
OP A140
DO 10.1136/hrt.2010.208967.449
VO 96
IS Suppl 3
A1 Jiyan Zhang
A1 Xiaodong Ge
A1 Ping Xu
A1 Suzhen Feng
YR 2010
UL http://heart.bmj.com/content/96/Suppl_3/A140.1.abstract
AB Objective To investigate the effects of cholesterol-lowering therapy with rosuvastatin calcium tablet on coronary flow reserve (CFR) patients with unstable angina pectoris (UAP) and hypercholesterolaemia. Method 40 patients with UAP were randomly divided into rosuvastatin calcium tablet therapeutic group (n=20) and conventional therapeutic group (n=20). By using colour Doppler ultrasound the coronary flow reserve was measured in patients with UAP before and after 3 rnonths cholesterol-lowering therapy. Result After cholesterol-lowering therapy for 3 months the serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG)decreased significaroly p<0.01. The coronary flow, reserve was increased from 1.92±0.41 to 2.97±0.62 (p<0.01). An inverse correlation was found not only between TC and C FR (r=−0.44, p<0.05) but also between LDL-C and CFR (r=0.47, p<0.05). Conclusion Cholesterol-lowering therapy with rosuvastatin calcium tablet may improve coronary flow reserve in patients with UAP and hypercholesterolaemia.