TY - JOUR T1 - Optical coherence tomography: has its time come? JF - Heart JO - Heart SP - 1361 LP - 1362 DO - 10.1136/hrt.2010.214825 VL - 97 IS - 17 AU - Alistair C Lindsay AU - Nicola Viceconte AU - Carlo Di Mario Y1 - 2011/09/01 UR - http://heart.bmj.com/content/97/17/1361.abstract N2 - Cardiologists using intravascular ultrasound (IVUS) towards the end of the past millennium can recall the time when enthusiasm for a method that was initially seen purely as a powerful research tool began to be substituted by the awareness that intravascular imaging had the potential to revolutionise our understanding of the mechanisms of coronary interventions. Such a revolution occurred in Milan when Antonio Colombo and his group applied ultrasound to elucidate the mechanism of stent thrombosis, at that time common despite high levels of anticoagulation.1Many early adopters of optical coherence tomography (OCT) have a similar perception now. A research tool initially confined to the interest of a few connoisseurs has now achieved more widespread attention, including among some practitioners not previously known to be particularly interested in intravascular imaging. Such is the rapidity of the phenomenon that it has caught most OCT experts by surprise, as well as the few current manufacturers of commercially available systems. This change is mainly attributed to a recent technical development—namely, the increased acquisition rate allowed by frequency domain OCT. A rapid pull-back at a speed of 2 cm/s minimises the amount of contrast required to clear blood during image acquisition, with an average injection of 15–18 ml now required for the maximal imaging length currently available of 5.6 cm.2 3 A further reason, however, is often neglected. The crisp separation between vessel wall and lumen and the definition of stent struts provided by … ER -