PT  - JOURNAL ARTICLE
AU  - Rachel R Huxley
AU  - Alvaro Alonso
AU  - Faye L Lopez
AU  - Kristian B Filion
AU  - Sunil K Agarwal
AU  - Laura R Loehr
AU  - Elsayed Z Soliman
AU  - James S Pankow
AU  - Elizabeth Selvin
TI  - Type 2 diabetes, glucose homeostasis and incident atrial fibrillation: the Atherosclerosis Risk in Communities study
AID  - 10.1136/heartjnl-2011-300503
DP  - 2012 Jan 15
TA  - Heart
PG  - 133--138
VI  - 98
IP  - 2
4099  - http://heart.bmj.com/content/98/2/133.short
4100  - http://heart.bmj.com/content/98/2/133.full
SO  - Heart2012 Jan 15; 98
AB  - Background Type 2 diabetes has been inconsistently associated with the risk of atrial fibrillation (AF) in previous studies that have frequently been beset by methodological challenges.Design Prospective cohort study.Setting The Atherosclerosis Risk in Communities (ARIC) study.Participants Detailed medical histories were obtained from 13 025 participants. Individuals were categorised as having no diabetes, pre-diabetes or diabetes based on the 2010 American Diabetes Association criteria at study baseline (1990–2).Main outcome measures Diagnoses of incident AF were obtained to the end of 2007. Associations between type 2 diabetes and markers of glucose homeostasis and the incidence of AF were estimated using Cox proportional hazards models after adjusting for possible confounders.Results Type 2 diabetes was associated with a significant increase in the risk of AF (HR 1.35, 95% CI 1.14 to 1.60) after adjustment for confounders. There was no indication that individuals with pre-diabetes or those with undiagnosed diabetes were at increased risk of AF compared with those without diabetes. A positive linear association was observed between HbA1c and the risk of AF in those with and without diabetes (HR 1.13, 95% CI 1.07 to 1.20) and HR 1.05, 95% CI 0.96 to 1.15 per 1% point increase, respectively). There was no association between fasting glucose or insulin in those without diabetes, but a significant association with fasting glucose was found in those with the condition. The results were similar in white subjects and African-Americans.Conclusions Diabetes, HbA1c level and poor glycaemic control are independently associated with an increased risk of AF, but the underlying mechanisms governing the relationship are unknown and warrant further investigation.