PT  - JOURNAL ARTICLE
AU  - Claire A Martin
AU  - Gareth D K Matthews
AU  - Christopher L-H Huang
TI  - Sudden cardiac death and inherited channelopathy: the basic electrophysiology of the myocyte and myocardium in ion channel disease
AID  - 10.1136/heartjnl-2011-300953
DP  - 2012 Apr 01
TA  - Heart
PG  - 536--543
VI  - 98
IP  - 7
4099  - http://heart.bmj.com/content/98/7/536.short
4100  - http://heart.bmj.com/content/98/7/536.full
SO  - Heart2012 Apr 01; 98
AB  - Mutations involving cardiac ion channels result in abnormal action potential formation or propagation, leading to cardiac arrhythmias. Despite the large impact on society of sudden cardiac death resulting from such arrhythmias, understanding of the underlying cellular mechanism is poor and clinical risk stratification and treatment consequently limited. Basic research using molecular techniques, as well as animal models, has proved extremely useful in improving our knowledge of inherited arrhythmogenic syndromes. This offers the practitioner tools to accurately diagnose rare disorders and provides novel markers for risk assessment and a basis for new strategies of treatment.