PT  - JOURNAL ARTICLE
AU  - Silje K Namtvedt
AU  - Jonny Hisdal
AU  - Anna Randby
AU  - Stefan Agewall
AU  - Einar Stranden
AU  - Virend K Somers
AU  - Helge Røsjø
AU  - Torbjørn Omland
TI  - Impaired endothelial function in persons with obstructive sleep apnoea: impact of obesity
AID  - 10.1136/heartjnl-2012-303009
DP  - 2013 Jan 01
TA  - Heart
PG  - 30--34
VI  - 99
IP  - 1
4099  - http://heart.bmj.com/content/99/1/30.short
4100  - http://heart.bmj.com/content/99/1/30.full
SO  - Heart2013 Jan 01; 99
AB  - Objective Obstructive sleep apnoea (OSA) and obesity are both associated with endothelial dysfunction, which precedes the development of atherosclerosis. As obesity is highly prevalent in OSA, we wanted to test the hypothesis that OSA is associated with endothelial dysfunction independently of obesity. Design Cross-sectional, population-based study. Setting Norwegian university hospital. Patients Seventy-one subjects (median age 44 years, 35% female) were recruited from a population-based study in Norway. Participants were categorised as obese (body mass index (BMI) ≥30 kg/m2), non-obese (BMI<30 kg/m2) with OSA (apnoea–hypopnoea index (AHI)≥10), or non-obese without OSA (AHI<5). Interventions None. Main outcome measures Endothelial function measured by brachial artery ultrasound and expressed as percentage of flow-mediated dilation (FMD%). Results When non-obese subjects without OSA were used as the reference (FMD% (mean±SD) 10.1±6.3), endothelial function was found to be impaired in subjects with OSA (FMD% 6.4±3.2) (p=0.003). FMD% did not differ between obese (6.0±3.4) and non-obese (6.7±3.1) OSA subjects (p=0.3). By univariate linear regression analysis, AHI, BMI, gender and baseline brachial artery diameter were significantly associated with FMD%. When these variables were entered into a multivariate model, only AHI was significantly associated with FMD%. Conclusions OSA is associated with endothelial dysfunction independently of obesity and conventional risk factors.