RT Journal Article
SR Electronic
T1 GW24-e3663 T1 Mapping for Detection of Left Ventricular Myocardial Fibrosis in Hypertrophic Cardiomyopathy: A Preliminary Study
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP A265
OP A265
DO 10.1136/heartjnl-2013-304613.749
VO 99
IS Suppl 3
A1 Lu MinJie
A1 Minjie Lu
A1 Shihua Zhao
A1 Gang Yin
A1 Shiliang Jiang
A1 Saurabh Shah
A1 Jing An
YR 2013
UL http://heart.bmj.com/content/99/Suppl_3/A265.2.abstract
AB Objectives To investigate the diagnostic value of T1 mapping imaging of evaluating fibrosis in patients with hypertrophic cardiomyopathy (HCM). Methods 21 subjects with HCM and 18 healthy volunteers underwent conventional late gadolinium enhancement (LGE) imaging and T1 mapping imaging. The region of myocardium in HCM is divided into remote area of LGE, peri-LGE, LGE(halo-like LGE and typical patchy LGE). These regions combined with normal volunteers' myocardium were calculated by the reduced percent of T1 value (RPTV). Results The RPTV in healthy volunteers was no significant comparing with that in the remote area of LGE in HCM subjects (3.98 ± 3.19 vs. 3.34 ± 2.75, P> 0.05). There were significant statistical differences in pairwise among the remote area of LGE, peri-LGE, halo-like LGE and typical patchy LGE in the RPTV (P <0.0001). ROC curves indicated that the T1 mapping imaging has a greater area under the curve comparing with that of traditional LGE imaging (0.975 ± 0.07 vs. 0.753 ± 0.26, P <0.0001). Conclusions HCM has a high prevalence of fibrosis and with varying severity. T1 mapping imaging can be a useful method to evaluate the severity of the fibrosis in HCM.