TY - JOUR T1 - Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study JF - Heart JO - Heart SP - 1837 LP - 1842 DO - 10.1136/heartjnl-2013-304739 VL - 99 IS - 24 AU - Tatsuya Maruhashi AU - Junko Soga AU - Noritaka Fujimura AU - Naomi Idei AU - Shinsuke Mikami AU - Yumiko Iwamoto AU - Masato Kajikawa AU - Takeshi Matsumoto AU - Takayuki Hidaka AU - Yasuki Kihara AU - Kazuaki Chayama AU - Kensuke Noma AU - Ayumu Nakashima AU - Chikara Goto AU - Hirofumi Tomiyama AU - Bonpei Takase AU - Akira Yamashina AU - Yukihito Higashi Y1 - 2013/12/15 UR - http://heart.bmj.com/content/99/24/1837.abstract N2 - Objective To determine the relationships between flow-mediated vasodilation (FMD) and cardiovascular risk factors, and to evaluate confounding factors for measurement of FMD in a large general population in Japan. Methods This was a cross-sectional study. A total of 5314 Japanese adults recruited from people who underwent health screening from 1 April 2010 to 31 August 2012 at 3 general hospitals in Japan. Patients’ risk factors (age, Body Mass Index, blood pressure, cholesterol parameters, glucose level and HbA1c level) and prevalence of cardiovascular disease (coronary heart disease and cerebrovascular disease) were investigated. Results Univariate regression analysis revealed that FMD correlated with age (r=−0.27, p<0.001), Body Mass Index (r=−0.14, p<0.001), systolic blood pressure (r=−0.18, p<0.001), diastolic blood pressure (r=−0.13, p<0.001), total cholesterol (r=−0.07, p<0.001), triglycerides (r=−0.10, p<0.001), high-density lipoprotein cholesterol (r=0.06, p<0.001), low-density lipoprotein cholesterol (r=−0.04, p=0.01), glucose level (r=−0.14, p<0.001), HbA1c (r=−0.14, p<0.001), and baseline brachial artery diameter (r=−0.43, p<0.001) as well as Framingham Risk score (r=−0.29, p<0.001). Multivariate analysis revealed that age (t value=−9.17, p<0.001), sex (t value=9.29, p<0.001), Body Mass Index (t value=4.27, p<0.001), systolic blood pressure (t value=−2.86, p=0.004), diabetes mellitus (t value=−4.19, p<0.001), smoking (t value=−2.56, p=0.01), and baseline brachial artery diameter (t value=−29.4, p<0.001) were independent predictors of FMD. Conclusions FMD may be a marker of the grade of atherosclerosis and may be used as a surrogate marker of cardiovascular outcomes. Age, sex, Body Mass Index, systolic blood pressure, diabetes mellitus, smoking and, particularly, baseline brachial artery diameter are potential confounding factors in the measurement of FMD. ER -