RT Journal Article
SR Electronic
T1 Resuscitated cardiac arrest and prognosis following myocardial infarction
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1125
OP 1132
DO 10.1136/heartjnl-2014-305696
VO 100
IS 14
A1 Albert E Alahmar
A1 Christopher P Nelson
A1 Kym I E Snell
A1 Matthew F Yuyun
A1 Muntaser D Musameh
A1 Adam Timmis
A1 John S Birkhead
A1 Sumeet S Chugh
A1 John R Thompson
A1 Iain B Squire
A1 Nilesh J Samani
YR 2014
UL http://heart.bmj.com/content/100/14/1125.abstract
AB Objectives To determine whether resuscitated cardiac arrest (CA) complicating ST elevation myocardial infarction (STEMI) impacts outcome, particularly in patients surviving to discharge. Background Resuscitated CA complicating STEMI is associated with increased inpatient mortality. The impact on later prognosis is unclear. Methods We analysed data from the UK Myocardial Ischaemia National Audit Project for STEMI patients admitted during January 2008–March 2010. We used survival analyses to assess the independent impact of resuscitated CA during the index episode on inhospital, 30 days, 1 year and medium term all-cause mortality. Results Of 48 749 STEMI patients, 5308 (10.9%) were recorded as having a CA. Of these, 1557 (29.3%) died on the day of CA. In survivors, after covariate adjustment, resuscitated CA was associated with increased risk of death during the index admission (HR 4.05 (3.69 to 4.45) p<0.001). In patients surviving to discharge, a history of resuscitated CA was associated with increased risk of death to 30 days (HR 1.53 (1.18 to 2.00), p<0.001). However, beyond 30 days, resuscitated CA was not associated with increased mortality risk (1-year HR 0.95 (0.79 to 1.14, p=0.596); 3.5 years HR 0.90 (0.78 to 1.04), p=0.144). The influence of resuscitated CA on inhospital or 30-day mortality was similar whether CA occurred before or after hospital admission. Where the resuscitated CA rhythm was asystole, inhospital mortality was higher compared with ventricular arrhythmia (p<0.001) or pulseless electrical activity (p=0.011). Late resuscitated CA (occurring after the day of index STEMI) was associated with higher 30-day postdischarge mortality compared with early resuscitated CA (p=0.023). Conclusions STEMI complicated by resuscitated CA merits careful monitoring in the early period postevent. In contemporary practice, there is no impact of resuscitated CA on longer-term prognosis.