MyBPC | β-MHC | |||||||
---|---|---|---|---|---|---|---|---|
Controls (n=79) | Non-penetrants (n=24) | Penetrants (n=35) | p Value* | Controls (n=33) | Non-penetrants (n=12) | Penetrants (n=23) | p Value* | |
Values are n or mean (SD). | ||||||||
*p Values for global variance analysis. | ||||||||
β-MHC, β-myosin heavy chain gene; BMI, body mass index; BP, blood pressure; LA, left atrial; LVMI, left ventricular mass index; MyBPC, cardiac myosin binding protein C gene; non-penetrant, genetically affected but no left ventricular hypertrophy; penetrant, genetically affected with left ventricular hypertrophy. | ||||||||
Male/female | 37/42 | 10/14 | 23/12 | NS | 19/14 | 6/6 | 14/9 | NS |
Age (years) | 37 (14) | 38 (19) | 45 (15) | 0.02 | 39 (14) | 34 (12) | 42 (15) | NS |
Heart rate (beats/min) | 68 (10) | 65 (12) | 66 (17) | NS | 73 (17) | 69 (17) | 65 (12) | NS |
BMI (kg/m2) | 23.5 (3.6) | 23.8 (3.1) | 24.7 (2.8) | NS | 22.8 (3.1) | 21.6 (2.8) | 23.7 (3.4) | NS |
Systolic BP (mm Hg) | 124 (11) | 126 (12) | 124 (11) | NS | 128 (9) | 119 (8) | 132 (21) | NS |
MWT (mm) | 9.2 (1.6) | 10.4 (1.7) | 17.6 (4.6) | 0.0001 | 10.2 (2.2) | 9.8 (1.8) | 20.9 (4.8) | 0.0001 |
LA diameter (mm) | 33 (6) | 35 (4) | 41 (9) | 0.0001 | 34 (5) | 35 (4) | 40 (9) | 0.03 |
LVMI (g/m2) | 37.8 (7.0) | 40.6 (8.0) | 57.9 (12.4) | 0.0001 | 36.6 (8.5) | 37.4 (10.0) | 63.7 (12.5) | 0.0001 |